August 4, 2022 – CDC researchers report that people with Corona Virus The risk of severe outcomes is about twice as high compared to others without COVID.
inflammation of the heart; blood clots in the lungs; or a blood clot In a new study, the lower legs, thighs or pelvis were the most common adverse outcomes. Although the risk of these and some other serious events is higher, the overall numbers are small.
“Many of these conditions were rare or uncommon in children in this analysis, but even a small increase in these conditions is noteworthy,” said a new statement from the CDC.
The researchers say their findings underscore the importance of vaccinating Americans under 18 against COVID-19.
This study Published online Thursday at the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report (MMWR).
Little is known about long-term COVID in children
Dr. Lyudmyla Kompaniyets and colleagues note that to date, most research on long-term COVID has been done in adults, so there is little information about the risks to Americans 17 and younger.
To learn more, they compared post-COVID-19 symptoms and conditions in 781,419 children and adolescents with confirmed COVID-19 with another 2,344,257 children and adolescents with undiagnosed COVID-19. They looked at medical claims and laboratory data from these children and adolescents between March 1, 2020, and January 31, 2022, to see who had any of 15 specific outcomes associated with long-term COVID.
Prolonged COVID is defined as symptoms that persist or begin at least 4 weeks after a COVID diagnosis.
Compared with children without a history of COVID-19 diagnosis, the long-term COVID-19 group was:
- 101% more likely to have an acute pulmonary embolism (blood clot in the lungs)
- 99% increased likelihood of having myocarditis (inflammation of the heart muscle) or cardiomyopathy (when the heart is weak and has trouble pumping)
- 87% increased likelihood of a venous thromboembolic event (venous thrombosis)
- 32% increased likelihood of acute and unspecified renal failure (when the kidneys are unable to filter waste from the blood)
- 23% more likely type 1 diabetes
“This report states that the risk of COVID infection itself, whether acute effects, MIS-C, or long-term effects, is real, concerning, and potentially very serious,” said Stuart Berger, MD, American Academy of Pediatrics Chairman of the Cardiology and Cardiac Surgery Branch.
MIS-C is Multisystem Inflammatory Syndrome in Children, a condition in which many parts of the body become inflamed and is associated with COVID-19.
“The message we should take from this is that we should be very enthusiastic about all the ways to prevent COVID, especially vaccinesaid Berger, who is also director of cardiology at Northwestern University Feinberg School of Medicine in Chicago.
a “wake-up call”
Gregory Poland, MD, an infectious disease specialist at the Mayo Clinic in Rochester, Minnesota, said the findings were “sobering” and “a reminder of the seriousness of COVID infection.”
“When you look specifically at the more serious complications of COVID in this younger cohort, those complications are life-changing and have consequences and repercussions throughout their lives,” he said.
“I would take this as a serious wake-up call for parents [at a time when] Immunization rates for young children are miserably low,” Poland said.
it’s too early
Peter Katona, a professor of medicine and an infectious disease specialist at the UCLA Fielding School of Public Health, said the study is instructive but not conclusive.
He said it was too early to draw conclusions about long-term COVID, including in children, as many questions remained, he said: Should long-term COVID be defined as symptoms 1 month or 3 months after infection?how do you define brain FOG?
Katona and colleagues are studying long-term COVID interventions among UCLA students to answer some of these questions, including the incidence and effects of early intervention.
The researchers noted that the study “has at least seven limitations.” One of these is the use of medical claims data, which document long-term COVID outcomes but do not say how severe they are; some people in the no-COVID group may have been ill but not diagnosed; researchers did not make adjustments.
Poland noted that the study was done during a surge in the outbreak COVID variants Including Delta and Omicron. In other words, any long-term COVID effects associated with newer variants like BA.5 or BA.2.75 are unknown.